A Brief Review of Short Tandem Repeat Mutation
نویسندگان
چکیده
منابع مشابه
A Brief Review of Short Tandem Repeat Mutation
Short tandem repeats (STRs) are short tandemly repeated DNA sequences that involve a repetitive unit of 1-6 bp. Because of their polymorphisms and high mutation rates, STRs are widely used in biological research. Strand-slippage replication is the predominant mutation mechanism of STRs, and the stepwise mutation model is regarded as the main mutation model. STR mutation rates can be influenced ...
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Short tandem repeats (STRs) have a wide range of applications, including medical genetics, forensics, and genetic genealogy. High-throughput sequencing (HTS) has the potential to profile hundreds of thousands of STR loci. However, mainstream bioinformatics pipelines are inadequate for the task. These pipelines treat STR mapping as gapped alignment, which results in cumbersome processing times a...
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ژورنال
عنوان ژورنال: Genomics, Proteomics & Bioinformatics
سال: 2007
ISSN: 1672-0229
DOI: 10.1016/s1672-0229(07)60009-6